Many of the early clinical successes using intravenous transplantation came in systemic diseases such as graft versus host disease and sepsis. Direct injection or placement of cells into a site in need of repair may be the preferred method of treatment, as vascular delivery suffers from a "pulmonary first pass effect" where intravenous injected cells are sequestered in the lungs.

Meplazumab (Ketantin®) is a lyophilized powder for injection of small volume. The main active ingredient of the product, meplazumab, is a humanized immunoglobulin (Ig) G2 monoclonal antibody, consisting of the complementary-determining regions of anti CD147 murine antibody and the human framework region. It acts as an erythrocytic stage-macromolecular antibody drug that has the potential to mediate both treatment and prophylaxis of falciparum malaria.

Лечение легких и среднетяжелых форм малярии, вызванной штаммами Р. falciparum, устойчивыми к другим противомалярийным препаратам, Р. vivax и малярии смешанной этиологии.

Низкомолекулярный гепарин, полученный путем деполимеризации из стандартного гепарина. Надропарин проявляет высокую способность к связыванию с белком плазмы крови антитромбином III (AT III). Это связывание приводит к ускоренному ингибированию фактора Ха. чем и обусловлен высокий антитромботический потенциал надропарина. 

Профилактика тромбоэмболических осложнений у пациентов с высоким риском тромбообразования (при острой дыхательной недостаточности и/или респираторной инфекции и/или сердечной недостаточности), находящихся в постельном режиме в связи с острой терапевтической патологией или госпитализированных в отделение реанимации или интенсивной терапии.

Nafamostat is a serine protease inhibitor and short-acting anti-coagulant. To gain entry into cells, the SARS-CoV-2 virus requires spike protein binding to the angiotensin-converting enzyme 2 (ACE2) and activation of the protease TMPRSS2. Nafamostat can inhibit TMPRSS2 protease function and is thus thought to be able to prevent viral entry into cells.

Niclosamide is a bioavailable chlorinated salicylanilide, with potential antiviral and known anthelmintic activity. Antihelminth activity is achieved by inhibiting glucose uptake, oxidative phosphorylation, and anaerobic metabolism in the tapeworm. Anticoronaviral activity is not well understood, but it is possible that niclosamide inhibits S-phase kinase-associated protein 2 (SKP2). SKP2 is known to tag Benclin 1 (BECN1) for degradation and SKP2 inhibition increases the BENC1 level, enhances autophagy, and efficiently reduces coronavirus replication.

Nitazoxanide is an effective first-line treatment for infection by Blastocystis species and is indicated for the treatment of infection by Cryptosporidium parvum or Giardia lamblia in immunocompetent adults and children. It is also an effective treatment option for infections caused by other protozoa and helminths (e.g., Entamoeba histolytica, Hymenolepis nana, Ascaris lumbricoides, and Cyclospora cayetanensis).

Олокизумаба (ингибитора интерлейкина-6) и RPH-104 (ингибитора интерлейкина-1)

Oseltamivir is a neuraminidase inhibitor, a competitive inhibitor of influenza's neuraminidase enzyme. The enzyme cleaves the sialic acid which is found on glycoproteins on the surface of human cells that helps new virions to exit the cell. Thus oseltamivir prevents new viral particles from being released.