Anakinra is a recombinant form of the human IL-Ra, r-metHuIL-1Ra, which is produced by recombinant DNA technology in an E. coli expression system. Therapeutically, anakinra neutralizes the biological activity of IL-1 (IL-1α and IL-1β) by competitively inhibiting its binding to the IL-1RI. , Emapalumab (previously referred to as NI-0501, trade name Gamifant®) is a fully human Immunoglobulin G1 (IgG1) Anti-Interferon gamma (IFNγ) monoclonal antibody that binds to and neutralizes IFNγ.
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