Investigational Humanized Monoclonal Antibody to the Chemokine Receptor CCR5. Leronlimab may enhance immune response while mitigating cytokine storm.
The first as a combination therapy with HAART for HIV-infected patients and the second is for metastatic triple-negative breast cancer. Leronlimab is an investigational humanized IgG4 mAb that blocks CCR5, a cellular receptor that is important in HIV infection, tumor metastases, and other diseases, including NASH. Leronlimab has completed nine clinical trials in over 800 people, including meeting its primary endpoints in a pivotal Phase 3 trial (leronlimab in combination with standard antiretroviral therapies in HIV-infected treatment-experienced patients).
An Emergency Investigational New Drug Application (eIND) has been granted by the FDA for treatment of patients experiencing respiratory complications due to SARS-CoV-2.
Use currently being evaluated in a small number of patients with severe COVID19 via the FDA eIND.
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