Interleukin 1 beta inhibitors; Interleukin 6 inhibitors; Tumour necrosis factor alpha inhibitors.
CD24Fc is designed to modulate host inflammatory response to tissue injuries which is believed to be involved in autoimmune disease, cancer, graft-versus-host disease (GvHD) and metabolic syndromes.
Has a dual mechanism of action. First, CD24Fc binds DAMPs (Danger-Associated Molecular Patterns), trapping the inflammatory stimuli to prevent their interaction with TLRs (Toll-like receptors). Second, CD24Fc binds Siglec G/10 and regulates host response to tissue injuries Siglec G/10-associated SHP1 inhibitory signaling. Both mechanisms likely act in concert to modulate immune responses.
Cell Mol Immunol. 2020 May 7. DOI: 10.1038/s41423-020-0452-5.