BLD-2660, synthetic small-molecule inhibitor of calpain. Calpains are a class of non-lysosomal cysteine proteases involved in diverse cellular processes. Several publications indicate that specific host calpains are essential for the replication of multiple RNA viruses including Coronaviruses. BLD-2660 has also been shown to normalize interleukin (IL)-6, a pro-inflammatory cytokine demonstrated to be elevated in COVID-19 patients and is implicated in disease pathogenesis.
Augmented Curation of Unstructured Clinical Notes from a Massive EHR System Reveals Specific Phenotypic Signature of Impending COVID-19 Diagnosis. April 30, 2020. DOI: 10.1101/2020.04.19.20067660., , et al.