Авиптадил (Aviptadil)
Международное непатентованное наименование
Авиптадил (Aviptadil)
Торговое наименование
-
Производитель, страна
OncoImmune, USA
Механизм действия
Aviptadil is a synthetic version of Vasoactive Intestinal Polypeptide (VIP). This protein is found throughout the body and contributes to numerous functions including vasodilation, increasing glycogenolysis, lowering arterial blood pressure, and relaxing the smooth muscles. VIP is highly concentrated in the lung, where it prevents NMDA-induced caspase-3 activation in the lung, inhibits IL6, and TNFa production. It is theorized that the delivery of this therapeutic will help with the serious lung complications associated with COVID-19.
Публикации COVID-19
, , et al. Augmented Curation of Unstructured Clinical Notes from a Massive EHR System Reveals Specific Phenotypic Signature of Impending COVID-19 Diagnosis. DOI: 10.1101/2020.04.19.20067660.
Клинические исследования
1.
Название протокола
Inhaled Aviptadil for the Treatment of Non-Acute Lung Injury in COVID-19
Дата начала и окончания КИ
June 1, 2020 - October 1, 2020
Название организации, проводящей КИ
NeuroRx, Inc.
Страны
USA
Фаза
II-III
Кол-во пациентов
144
2.
Название протокола
Intravenous Aviptadil for COVID-19 Associated Acute Respiratory Distress
Дата начала и окончания КИ
May 15, 2020 - September 2020
Название организации, проводящей КИ
NeuroRx, Inc.
Страны
Israel, USA
Фаза
II
Кол-во пациентов
144